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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Category 1 external quality assessment program for serum creatinine.

Elisabet González-Lao1,2, Jorge Díaz-Garzón1,3, Zoraida Corte1,4

  • 1Spanish Society of Laboratory Medicine (SEQC-ML), Analytical Quality Commission, Spain.

Annals of Translational Medicine
|May 3, 2017
PubMed
Summary
This summary is machine-generated.

This study assessed serum creatinine measurement standardization in Spanish labs using an External Quality Assessment Program (EQAP). Enzymatic methods proved most reliable, highlighting the need for wider adoption to improve accuracy.

Keywords:
Creatininecommutabilityexternal quality assessment programs (EQAP)standardizationtraceability

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Quality

Background:

  • First national Category 1 External Quality Assessment Program (EQAP) for serum creatinine in Spain.
  • Organized by the Spanish Society of Laboratory Medicine (SEQC) and Dutch Foundation for Quality.
  • Utilized commutable material and reference method values for evaluation.

Purpose of the Study:

  • Evaluate the standardization of serum creatinine measurements across Spanish laboratories.
  • Assess the effectiveness of a Category 1 EQAP in a national setting.
  • Identify methods achieving satisfactory standardization.

Main Methods:

  • 87 Spanish laboratories participated in 2015.
  • Duplicate sample controls measured daily for 6 days.
  • Results compared against biological variation quality specifications.

Main Results:

  • 1044 creatinine results analyzed.
  • 11 different method-traceability combinations identified.
  • Only enzymatic methods consistently met acceptability limits.

Conclusions:

  • Category 1 EQAP participation is crucial for assessing national standardization.
  • Promoting enzymatic creatinine methods is essential for improving standardization.
  • Efforts needed to encourage laboratories to adopt standardized procedures.