Related Experiment Video

Updated: Mar 3, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.6K

Gastric Cancer in the Era of Precision Medicine

Xi Liu1,2, Stephen J Meltzer2

  • 1Department of Pathology, First Affiliated Hospital of Xi' an Jiaotong University, Xi' an, Shaanxi, China.

Cellular and Molecular Gastroenterology and Hepatology
|May 3, 2017
PubMed

Insights

Gastric cancer (GC) research is advancing rapidly through next-generation sequencing and novel preclinical models. These tools are revolutionizing the understanding of GC subtypes and paving the way for precision medicine approaches.

Area of Science:

  • Oncology
  • Genomics
  • Translational Medicine

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally, characterized by limited effective therapeutic options.
  • Recent advancements in genomic technologies and preclinical models are transforming the understanding of GC pathogenesis.

Purpose of the Study:

  • To review the current understanding of the genomic landscape of gastric cancer.
  • To highlight the role of novel preclinical models in advancing GC research and personalized medicine.

Main Methods:

  • Genomic characterization using next-generation sequencing.
  • Development and application of patient-derived tumor xenografts and organoids.
  • Integration of clinical, genomic, and phenotypic data.

Main Results:

  • The genomic landscape of GC has been significantly delineated, revealing molecular subtypes.
  • Novel therapeutic targets have been identified for specific GC molecular subtypes.
  • Patient-derived models are effective for biomarker discovery and drug screening.

Conclusions:

  • Advances in genomics and preclinical models are revolutionizing gastric cancer research.
  • These tools facilitate the development of personalized medicine strategies for GC patients.
  • Integrating diverse data types is crucial for advancing precision oncology in gastric cancer.
Keywords:
CIMP, CpG island methylator phenotypeCIN, chromosomally unstable/chromosomal instabilityCancer GenomicsEBV, Epstein-Barr virusGAPPS, gastric adenocarcinoma and proximal polyposis of the stomachGC, gastric cancerGTPase, guanosine triphosphataseGastric CancerHDGC, hereditary diffuse gastric cancerLOH, loss of heterozygosityMSI, microsatellite unstable/instabilityMSI-H, high microsatellite instabilityMSS/EMT, microsatellite stable with epithelial-to-mesenchymal transition featuresMolecular ClassificationNGS, next-generation sequencingPDX, patient-derived tumor xenograftsPreclinical ModelsTCGA, The Cancer Genome AtlasTGF, transforming growth factorhPSC, human pluripotent stem celllncRNA, long noncoding RNAmiRNA, microRNA

More Related Videos

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.3K
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.8K

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
53