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Neonatal factors among subjects diagnosed with a pervasive developmental disorder in the US

David Geier1,2, Janet Kern1,2,3, Mark Geier1,2

  • 1a The Institute of Chronic Illnesses, Inc , Silver Spring , MD , USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 3, 2017
PubMed

Insights

This study found no significant differences in neonatal factors between children diagnosed with pervasive developmental disorder (PDD) and controls. The male/female ratio was higher in cases, but birth weight, gestational age, and APGAR scores did not differ.

Area of Science:

  • Neonatal factors
  • Neurodevelopmental disorders
  • Autism Spectrum Disorder research

Background:

  • Pervasive developmental disorder (PDD) diagnosis has been linked to neonatal factors in prior studies.
  • Limited longitudinal data exists from prospective medical record assessments.

Purpose of the Study:

  • To evaluate birth characteristics in children diagnosed with PDD compared to controls.
  • To utilize prospective medical record data for hypothesis testing.

Main Methods:

  • Longitudinal, case-control study design.
  • Utilized the Vaccine Safety Datalink (VSD) database for prospectively collected automated medical records.
  • Compared birth characteristics including gender, gestational age, birth weight, APGAR scores, and maternal age.

Main Results:

  • Cases diagnosed with PDD showed a significantly increased male/female ratio compared to controls.
  • No statistically significant differences were found in mean gestational age, birth weight, maternal age, or APGAR scores between cases and controls.

Conclusions:

  • Neonatal factors, excluding gender ratio, do not appear to significantly differentiate children diagnosed with PDD from controls.
  • This study contributes to understanding the etiology of PDD by ruling out certain neonatal risk factors.
Abstract

Keywords:
AspergerPDD-NOSautismgestational ageneonatal

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