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Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients
D S Anson1, D J Blake, P R Winship
1Sir William Dunn School of Pathology, University of Oxford, UK.
The EMBO Journal
|September 1, 1988
Abstract:
The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3' of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.