Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

3.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.4K
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

854
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
854
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

1.0K
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
1.0K
Physiological Control of Respiration01:23

Physiological Control of Respiration

6.5K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indications, techniques, and safety of cryotherapy and cryobiopsy via flexible bronchoscopy in pediatric patients.

Annals of the American Thoracic Society·2026
Same author

Endobronchial Lesions in Children: Radiologic, Bronchoscopic, and Pathologic Correlation.

Radiographics : a review publication of the Radiological Society of North America, Inc·2026
Same author

Endoscopic tracheoesophageal fistula closure-Electrocautery combined with esophageal clip application in pediatric patients.

Journal of pediatric gastroenterology and nutrition·2026
Same author

CDK4/6 Inhibitors Plus Endocrine Therapy in Early-Stage HR+/HER2- Breast Cancer: Updated Meta-Analysis of Phase III Trials.

Cancers·2025
Same author

Lower Respiratory Tract Bacterial Profiles Are Associated With Respiratory Severity and Bronchopulmonary Dysplasia in Neonates.

Pediatric pulmonology·2025
Same author

In Response to A Clinical Consensus Statement on Pulmonary Recurrent Respiratory Papillomatosis.

The Laryngoscope·2025

Related Experiment Video

Updated: Mar 3, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

13.7K

Neuromuscular disorders and chronic ventilation.

Stamatia Alexiou1, Joseph Piccione2

  • 1Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Seminars in Fetal & Neonatal Medicine
|May 3, 2017
PubMed
Summary

Infants with neuromuscular disease face respiratory issues due to muscle weakness. Non-invasive ventilation can improve breathing, daytime function, and symptoms, but understanding its benefits and limitations is crucial.

Keywords:
HypercapniaMechanical ventilationNeuromuscular diseaseNon-invasive ventilation

More Related Videos

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

1.2K
Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
09:43

Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons

Published on: May 25, 2015

18.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

13.7K
3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

1.2K
Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
09:43

Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons

Published on: May 25, 2015

18.3K

Area of Science:

  • Pediatric Pulmonology
  • Neuromuscular Disorders
  • Respiratory Physiology

Background:

  • Therapies augmenting cough and ventilation have reduced morbidity and mortality in neuromuscular disease.
  • Infants with progressive neuromuscular disease are prone to respiratory complications from muscle weakness.
  • Increased respiratory loads can overwhelm compensatory mechanisms in affected infants.

Purpose of the Study:

  • To elucidate the respiratory physiology in infants with progressive neuromuscular disease.
  • To detail the benefits and limitations of assisted ventilation in this population.
  • To underscore the importance of understanding respiratory mechanics for managing neuromuscular disease.

Main Methods:

  • Observational studies on respiratory parameters in infants with neuromuscular disease.
  • Analysis of nocturnal hypercapnia as an indicator for ventilation initiation.
  • Review of literature on the effects of non-invasive ventilation on sleep-disordered breathing and daytime function.

Main Results:

  • Nocturnal hypercapnia frequently triggers the initiation of non-invasive ventilation.
  • Non-invasive ventilation may improve sleep-disordered breathing in affected infants.
  • Assisted ventilation can positively impact daytime function and reduce symptoms related to hypercapnia.

Conclusions:

  • Understanding respiratory physiology is essential for managing infants with neuromuscular disease.
  • Non-invasive ventilation offers significant benefits for respiratory support and overall function.
  • Careful consideration of both benefits and limitations of assisted ventilation is necessary for optimal patient care.