Related Experiment Video
Updated: Mar 3, 2026
11:17
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
12.6K
Delayed genital blisters following iodixanol administration
Wen Zhang1,2, Wei Yuan3, Hai-Ling Yuan1
1a Department of Pharmacy , Anning Branch Lanzhou General Hospital Lanzhou Command , Lanzhou , Gansu , P.R. China.
Clinical Toxicology (Philadelphia, Pa.)
|May 3, 2017
Summary
Delayed genital blisters are a rare adverse effect of iodixanol, a non-ionic contrast medium. This case report highlights a new potential side effect of iodixanol following digital subtraction angiography.
Area of Science:
- Radiology
- Pharmacology
Background:
- Iodixanol is a widely used non-ionic contrast medium for vascular imaging.
- Common adverse effects include skin reactions like rashes and hives, and angioedema.
Observation:
- A patient developed delayed genital blisters.
- These blisters appeared one day after undergoing digital subtraction angiography.
Findings:
- This is the first reported case of iodixanol-induced delayed genital blisters.
- The adverse reaction occurred despite iodixanol's general safety profile.
Implications:
- Highlights a previously undocumented adverse effect of iodixanol.
- Clinicians should be aware of this potential reaction when using iodixanol for angiography.
- Further investigation into the mechanism of this specific adverse event may be warranted.
Related Concept Videos
01:17Drugs for Treatment of Diarrhea-Predominant IBS
799
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
799
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
91
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
91
01:21Drugs for Treatment of Constipation-Predominant IBS
1.0K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.0K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
976
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
976
01:01Hypersensitivity Reactions: Cytolytic Reactions
74
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
74
01:17Chronic Bowel Disorders: Introduction
855
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
855