Calcifying pseudoneoplasm of the spine: imaging and pathological features

Area of Science:

• Neurology
• Pathology
• Radiology

Background:

• Calcifying pseudoneoplasms of the neuraxis are exceptionally rare, benign, non-neoplastic calcified lesions within the central nervous system.
• These lesions occur with similar frequency in the brain and spine, and can be intra-axial or extra-axial.
• Symptoms typically arise from mass effect, as these lesions are generally non-infiltrative.

Purpose of the Study:

• To report a unique case of calcifying pseudoneoplasm of the neuraxis.
• To describe its presentation in the spine with adhesive features and intradural extension.
• To emphasize the importance of imaging and clinical information in diagnosis.

Main Methods:

• Case report of a 67-year-old male patient.
• Clinical presentation including lower extremity weakness and gait instability.
• Diagnostic evaluation involving imaging and histological analysis.

Main Results:

• The patient presented with symptoms indicative of spinal cord compression.
• Imaging and histological findings confirmed a calcifying pseudoneoplasm of the neuraxis.
• The lesion demonstrated adhesive features and intradural extension, a rare characteristic.

Conclusions:

• Calcifying pseudoneoplasms of the neuraxis, though benign, can present uniquely.
• Spinal involvement with intradural extension is possible and can cause significant neurological deficits.
• Accurate diagnosis relies on integrating clinical data with detailed imaging and histopathological examination.