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Updated: Mar 3, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Steroid-AuI -NHC Complexes: Synthesis and Antibacterial Activity
Alba Vellé1,2,3, Ronan Maguire3, Kevin Kavanagh3
1Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea, ISQCH, Universidad de Zaragoza-CSIC, 50009, Zaragoza, Spain.
Abstract:
A series of gold(I) pioneer complexes bearing N-heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R2 -imidazol-2-ylidene)(steroid)] (where R=CH3 or CH2 CH2 OCH3 ) were synthesized, and the X-ray structure of a rare of gold(I)-estradiol derivative is discussed. Toxicity studies reveal notable antibacterial activity of the gold-based compounds, which is significantly increased in vivo by the presence of the estradiol unit. Toxicity profiling was estimated in vitro versus Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, and in vivo on Galleria mellonella larvae against E. coli.
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