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Related Concept Videos

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
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Determination of Crystal Structures01:29

Determination of Crystal Structures

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In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
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X-ray Crystallography02:18

X-ray Crystallography

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The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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Related Experiment Video

Updated: Mar 3, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
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On-the-Fly Data Assessment for High-Throughput X-ray Diffraction Measurements.

Fang Ren1, Ronald Pandolfi2, Douglas Van Campen1

  • 1Stanford Synchrotron Radiation Lightsource , SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.

ACS Combinatorial Science
|May 3, 2017
PubMed
Summary
This summary is machine-generated.

Automated data assessment enhances scientific discovery by enabling real-time analysis of experimental data. This approach optimizes resource use and data quality at national user facilities.

Keywords:
X-ray diffractionattribute extractiondata quality assessmenthigh-throughputon-the-fly

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Area of Science:

  • Materials Science
  • Data Science
  • Scientific Instrumentation

Background:

  • Accelerated data acquisition from advanced instrumentation presents challenges in timely data quality assessment.
  • Current methods lead to suboptimal data and coverage, necessitating data recollection and inefficient resource use.

Purpose of the Study:

  • To develop an automated, real-time approach for instantaneous data quality assessment.
  • To improve the efficiency and impact of scientific data collection and analysis.

Main Methods:

  • Real-time extraction and visualization of customized data attributes.
  • Development of an automated system for routine data assessment.

Main Results:

  • Instantaneous highlighting of data quality, coverage, and scientifically relevant information.
  • Improved data quality and optimized usage of characterization resources through prioritized measurements.

Conclusions:

  • Automated, real-time data assessment is crucial for leveraging high-speed data acquisition.
  • This approach serves as a foundation for sophisticated decision-trees to maximize scientific content and data quality.