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Updated: Mar 3, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Total Synthesis of Tedarene A
Kelly Maurent1, Corinne Vanucci-Bacqué1, Nathalie Saffon-Merceron2
1UMR CNRS 5068, LSPCMIB, Université Paul Sabatier , 118 Route de Narbonne, Toulouse, 31062 Cedex 9, France.
Abstract:
Tedarene A is a macrocyclic diaryl ether heptanoid isolated from the marine sponge Tedania ignis showing an inhibitory effect against nitric oxide production. The first total synthesis of tedarene A was achieved starting from the commercially available 3-(4-methoxyphenyl)propan-1-ol in nine steps and 15.3% overall yield. The synthetic sequence featured an E,Z-dienic bond introduction and a macrocyclization under Ullman conditions. During the synthesis, the E,E-isomer of tedarene A was also obtained and fully characterized.
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