Metabolic PET Imaging in Oncology.
Kiran Kumar Solingapuram Sai1, Zuzana Zachar2, Paul M Bingham2
11 Department of Radiology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157.
AJR. American Journal of Roentgenology
|May 3, 2017
Summary
Cancer cells alter metabolism for growth. Molecular imaging, like Positron Emission Tomography (PET), detects these metabolic changes for cancer diagnosis.
Area of Science:
- Biochemistry
- Oncology
- Medical Imaging
Background:
- Cancer cells exhibit altered metabolic pathways compared to normal cells.
- These metabolic alterations are crucial for rapid cell proliferation and survival.
- Understanding these differences is key for developing diagnostic strategies.
Purpose of the Study:
- To provide an overview of metabolic pathway subversion by cancer cells.
- To explain how molecular imaging can exploit metabolic differences for cancer diagnosis.
Main Methods:
- Review of cancer cell metabolism.
- Discussion of molecular imaging techniques, specifically Positron Emission Tomography (PET).
Main Results:
- Cancer cells reprogram key metabolic pathways to meet their high energy demands.
- Molecular imaging can visualize and quantify these metabolic alterations.
Conclusions:
- Molecular imaging, particularly PET, offers valuable insights into cancer-specific metabolic dysregulation.
- PET can serve as a diagnostic tool by detecting these metabolic anomalies.
Related Concept Videos
01:29Positron Emission Tomography
7.8K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.8K
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
678
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
678
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
538
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
538