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Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
Published on: September 27, 2024
Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue
Guanping Feng1, Marien Ochoa1,2, Jason R Maher1
1The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627.
Abstract:
The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.
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