Related Experiment Video
Updated: Mar 3, 2026
07:03
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
7.3K
Limbic grey matter changes in early Parkinson's disease.
Xingfeng Li1,2, Yue Xing1,2, Stefan T Schwarz1,2
1Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom.
Human Brain Mapping
|May 3, 2017
Summary
Early Parkinson's disease (PD) shows reduced grey matter in the right amygdala, linked to non-motor symptoms. This study reveals early limbic system changes and altered brain networks in PD patients.
Area of Science:
- Neuroimaging
- Neurology
- Neuroscience
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder.
- Non-motor symptoms are prevalent in early PD.
- Limbic system involvement in PD is not fully understood.
Purpose of the Study:
- Investigate local and network-related changes in limbic grey matter in early PD.
- Examine the relationship between grey matter changes and non-motor symptom severity.
- Identify early pathological markers in the limbic system.
Main Methods:
- Voxel-based morphometry applied to 538 T1 MRI scans from the Parkinson's Progression Markers Initiative.
- Comparison of grey matter density between early PD patients (n=366) and healthy controls (n=172).
- Structural brain network analysis using covariance seeded in abnormal regions.
Main Results:
- Reduced grey matter density in the right amygdala in early PD patients.
- Right amygdala grey matter correlated negatively with autonomic dysfunction and positively with cognitive performance.
- Altered structural connectivity of the right amygdala with cerebellum, thalamus, and temporal cortices.
- Increased age-related grey matter change in the limbic system of PD patients.
Conclusions:
- Early PD is characterized by limbic grey matter deficits, particularly in the right amygdala.
- These deficits are associated with specific non-motor symptoms and altered brain connectivity.
- Findings suggest early limbic pathology and extranigral spread in Parkinson's disease.
Related Concept Videos
01:37Neural Regulation
43.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.8K
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K