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A study of the interface between human bone and hydroxylapatite. A morphological and morphometric investigation
E C Marinoni1, R Simonatti, A Memeo
13rd Orthopaedic Clinic, University of Milan.
Italian Journal of Orthopaedics and Traumatology
|December 1, 1987
Summary
Dense hydroxylapatite screws show excellent biocompatibility with human bone in clinical trials for tibia fractures. This biomaterial holds promise for future orthopedic applications.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Bone Regeneration
Background:
- Fractures of the tibia often require surgical intervention with internal fixation.
- Biocompatible materials are crucial for successful bone healing and integration.
- Hydroxylapatite is a synthetic bone mineral with potential osteoconductive properties.
Purpose of the Study:
- To evaluate the biocompatibility of dense hydroxylapatite screws in human subjects.
- To investigate the bone-hydroxylapatite interface following implantation.
- To assess the potential clinical applications of hydroxylapatite in orthopedic fixation.
Main Methods:
- Clinical experiments involving four volunteers with tibia fractures.
- Use of dense hydroxylapatite screws alongside conventional internal fixation.
- Analysis of explanted screws and bone cores using conventional and scanning electron microscopy.
- Dichromatic bone mineralometric tests.
Main Results:
- Hydroxylapatite screws demonstrated excellent biocompatibility with human bone.
- Successful integration and interaction observed between hydroxylapatite and bone tissue.
- No adverse reactions reported related to the hydroxylapatite screws.
Conclusions:
- Dense hydroxylapatite exhibits excellent biocompatibility in vivo.
- Hydroxylapatite shows potential as a biomaterial for orthopedic fixation devices.
- Further clinical investigation is warranted for the application of hydroxylapatite in bone fracture treatment.