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Published on: May 28, 2019
Platelet to Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial
Xi-Peng Sun1, Jing Li1, Wei-Wei Zhu1
11 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Insights
A higher platelet-to-lymphocyte ratio (PLR) is linked to contrast-induced nephropathy (CIN) in ST-segment elevation myocardial infarction (STEMI) patients. This finding suggests PLR may predict CIN risk following primary percutaneous coronary intervention (pPCI).
Area of Science:
- Cardiology
- Nephrology
- Hematology
Background:
- Contrast-induced nephropathy (CIN) is a complication in patients undergoing procedures with contrast media.
- ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI) are at risk for CIN.
- The platelet-to-lymphocyte ratio (PLR) is a marker of inflammation and has been explored as a predictor for various conditions.
Purpose of the Study:
- To investigate the association between the platelet-to-lymphocyte ratio (PLR) and the incidence of contrast-induced nephropathy (CIN).
- To determine if PLR is an independent predictor of CIN in patients with STEMI undergoing pPCI.
Main Methods:
- A cohort of 5719 patients with STEMI undergoing pPCI was retrospectively analyzed.
- PLR was calculated from admission blood counts.
- CIN was defined as an increase in serum creatinine within 72 hours post-contrast administration.
Main Results:
- Contrast-induced nephropathy (CIN) occurred in 4.4% of patients (252/5719).
- Patients who developed CIN had a significantly higher PLR compared to those without CIN (173.8 vs. 116.2, P < .001).
- Logistic regression identified PLR as an independent predictor of CIN (OR: 1.432, 95% CI: 1.205-1.816, P = .031), alongside other clinical factors.
Conclusions:
- Elevated PLR is an independent risk factor for developing CIN in STEMI patients undergoing pPCI.
- PLR may serve as a useful predictive biomarker for CIN in this patient population.
- Further research could explore the mechanisms linking PLR to CIN and its clinical implications.
Abstract:
We investigated the relationship between platelet to lymphocyte ratio (PLR) and contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We enrolled 5719 patients in 3 tertiary hospitals from January 2005 to December 2010. The PLR was calculated as the ratio of platelet to lymphocyte counts on admission. Serum creatinine level was measured before and within 72 hours after contrast medium administration. To evaluate the relation between PLR and CIN, the 5719 patients were divided into a CIN group and a non-CIN group. Contrast-induced nephropathy occurred in 252 (4.4%) patients. Patients in the CIN group had significantly higher PLR than those in the non-CIN group (173.8 [62.3] and 116.2 [51.7], respectively; P < .001). In logistic regression analysis, PLR was an independent predictor of CIN (odds ratio: 1.432, 95% confidence interval: 1.205-1.816, P = .031), along with age, diabetes mellitus, creatinine, estimated glomerular filtration rate, and neutrophil to lymphocyte ratio. In conclusion, a higher PLR was an independent risk factor for the development of CIN in patients with STEMI undergoing pPCI.
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