In-house production and control of a few 99mTc-radiopharmaceuticals

The methodology adopted for the in-house preparation of seven types of "kits" used in the formulation of 99mTc-radiopharmaceuticals, viz. reticuloendothelial, hepatobiliary, renal, skeletal and blood-pool agents, and their control is described. The quality control was performed primarily by following pharmacokinetic patterns (both early vascular "dynamic" and late "static" phases) of the respective radiopharmaceuticals in Wistar strain rats subsequent to i.v. administration of the radiopharmaceuticals. The results obtained could be utilized for quality assurance of 99mTc-radiopharmaceuticals; especially those prepared in-house (from "kits") and use in diagnostic nuclear medicine. The in-house preparation of these "kits" in hospital radiopharmacy laboratories possessing adequate manufacturing facilities, skills and expertise could result in considerable savings in costs (of kits).