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Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls?

Ç Aydoğmuş1, N A Ayaz2, M Çakan2

  • 1Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Pediatric Allergy-Immunology Unit, Turkey.

Allergologia Et Immunopathologia
|May 4, 2017
PubMed

Insights

Familial Mediterranean fever (FMF) patients showed no increased risk for atopic dermatitis, allergic rhinitis, or asthma. However, immunoglobulin E (IgE) levels were significantly higher in children with FMF compared to controls.

Area of Science:

  • Pediatric Rheumatology
  • Allergology
  • Immunology

Background:

  • Limited and conflicting studies exist on atopy prevalence in Familial Mediterranean fever (FMF) patients.
  • Investigating atopy in FMF is crucial due to potential overlapping inflammatory pathways.

Purpose of the Study:

  • To evaluate the prevalence of atopy in children diagnosed with FMF.
  • To compare atopy markers between FMF patients and healthy controls.

Main Methods:

  • A cohort of 118 children with FMF and 50 healthy controls were assessed.
  • Evaluations included rhinitis, atopic dermatitis, urticaria, asthma, IgA, IgM, IgG, IgE levels, eosinophil counts, and skin prick tests (SPT).

Main Results:

  • Children with FMF had significantly higher mean IgE levels than controls (p<0.05).
  • SPT positivity rates were similar between FMF patients (13%) and controls (8.2%).
  • Prevalence of atopic dermatitis, allergic rhinitis, and asthma were 5.08%, 28.8%, and 15.25% in FMF patients, versus 0%, 36%, and 14% in controls, respectively.

Conclusions:

  • Children with FMF do not exhibit an increased prevalence of atopic dermatitis, allergic rhinitis, or asthma compared to controls.
  • Elevated IgE levels in FMF patients warrant further investigation into their clinical significance.
Abstract

Keywords:
Allergic rhinitisAllergyAsthmaAtopyEczemaFamilial Mediterranean feverTh1Th17Th2

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