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Unbound monomers do diffuse through the dentin barrier.

Kods Mahdhaoui1, Benjamin Fournier2, Mathieu A Derbanne1

  • 1Unité de Recherche en Biomatériaux Innovants et Interfaces (URB2I)-EA4462, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris Cité, 1 rue Maurice Arnoux, 92120 Montrouge, France.

Dental Materials : Official Publication of the Academy of Dental Materials
|May 4, 2017
PubMed
Summary

Dentinal fluid proteins, like albumin, significantly influence the diffusion of dental adhesive monomers through dentin. This suggests a new pathway for resin monomer cytotoxicity, impacting dental pulp exposure.

Keywords:
AlbuminBiocompatibilityCytotoxicityDental adhesivesDentinMonomersPulp

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Polymer Chemistry

Background:

  • Dental adhesives release unpolymerized monomers.
  • Trans-dentinal diffusion of these monomers to the pulp is a concern.
  • The role of dentinal fluid proteins in this diffusion is not fully understood.

Purpose of the Study:

  • To investigate the effect of dentinal fluid proteins on the trans-dentinal diffusion of free monomers from dental adhesives.
  • To explore the potential role of albumin in transporting monomers through dentin.

Main Methods:

  • Human dentin disks were used with an artificial pulp chamber.
  • A simplified etch-and-rinse adhesive containing HEMA and BisGMA was tested.
  • Extraction media included buffered saline and saline with bovine serum albumin (BSA).
  • Monomer diffusion was quantified using High-Performance Liquid Chromatography (HPLC).

Main Results:

  • Quantifiable amounts of HEMA diffused into both media.
  • BisGMA was detected only in the BSA-containing medium.
  • Monomer concentrations were significantly higher in the BSA medium, indicating enhanced diffusion.

Conclusions:

  • Albumin, a dentinal fluid protein, can transport hydrophobic monomers like BisGMA.
  • Dentinal fluid proteins may significantly affect monomer diffusion to the pulp.
  • This highlights a potential mechanism for resin monomer-induced cytotoxicity.