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Updated: Mar 3, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Human Papilloma Virus' Life Cycle and Carcinogenesis
Petros Pinidis1, Panagiotis Tsikouras1, Georgios Iatrakis2
1Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
Rationale:
Considering that the loss of cell cycle and apoptosis control constitutes a central event in human papilloma virus' (HPV)-mediated carcinogenesis, the reason of this study is to insight to the HPV life cycle.
Objective:
The purpose of the study is to analyze the HPV molecular biology and cervical cancer association.
Methods And Results:
Brief review of current literature on the HPV life cycle and cervical carcinogenesis.
Discussion:
Among the HPV associated cancers, cervical cancer still ranks number two in the global cancer incidence of women. A central component of the association between HPV and cervical carcinogenesis is the ability of HPV to persist in the lower genital tract for long periods of time without being cleared because of its evasion mechanisms.
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