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Updated: Mar 3, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Thrombophilia-Related Complications in the Treatment of a Left Atrial Appendage Thrombus: A Case Report

Vito Maurizio Parato1, Michele Scarano1, Benedetto Labanti1

  • 1Cardiology Unit and Echo-Lab of Emergency Department, Madonna del Soccorso Hospital, San Benedetto del Tronto, Italy.

Journal of Cardiovascular Echography
|May 4, 2017
PubMed

Trans-esophageal echocardiography (TEE) revealed a left atrial appendage (LAA) thrombus in an 84-year-old woman with nonvalvular atrial fibrillation not known before our evaluation. In her medical history, there were hypertension, dyslipidemia and a previous pulmonary embolism. She was taking warfarin at time of our evaluation and presented signs and symptoms of heart failure. Together with heart failure treatment, intravenous anticoagulation with unfractionated heparin was initiated. Treatment was complicated by additional right lower limb embolic event and the LAA thrombus remained unchanged. Testing revealed heterozygosity for both the factor V Leiden and the methylenetetrahydrofolate reductase C677T mutations inducing resistance to activated protein C. The patient refused transcatheter closure of the left atrial appendage.

Keywords:
Left atrial appendagethrombophiliathrombustrans-esophageal echocardiography

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