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Exercise as a Positive Modulator of Brain Function.

Karim A Alkadhi1

  • 1Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77204, USA. kalkadhi@uh.edu.

Molecular Neurobiology
|May 4, 2017
PubMed
Summary
This summary is machine-generated.

Regular exercise can help prevent and treat brain disorders like dementia and Parkinson's disease. This review explores how physical activity and exercise mimetics impact brain function and discusses underlying mechanisms.

Keywords:
Animal voluntary and forced exerciseBDNFElectrophysiologyHuman aerobic and anaerobic exerciseLong-term potentiationMeditation

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Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Neurology

Background:

  • Brain disorders such as dementias, Parkinson's disease, chronic stress, thyroid disorders, and sleep deprivation pose significant health challenges.
  • Exercise is increasingly recognized for its potential to prevent, restore, or ameliorate these neurological and psychiatric conditions.

Purpose of the Study:

  • To review and compare the effects of various exercise forms and exercise mimetics on brain function in humans and animal models.
  • To discuss the potential mechanisms underlying the neuroprotective and restorative benefits of exercise.

Main Methods:

  • Comparative review of existing human and animal studies on exercise and brain function.
  • Analysis of research on exercise mimetics as potential therapeutic agents.
  • Discussion of neurobiological pathways, including neurotrophic factors, implicated in exercise's effects on the brain.

Main Results:

  • Exercise demonstrates broad efficacy in preventing and treating a range of brain disorders.
  • Exercise mimetics show promise as alternative or supplementary interventions.
  • Neurotrophic factors and other biological mechanisms are key mediators of exercise-induced brain benefits.

Conclusions:

  • Physical activity is a powerful non-pharmacological intervention for brain health.
  • Further research into exercise mimetics could yield novel therapeutic strategies.
  • Understanding the molecular mechanisms of exercise is crucial for optimizing brain disorder treatments.