Recent progress in biomedical applications of persistent luminescence nanoparticles

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Persistent luminescence nanoparticles (PLNPs) exhibit luminescence after excitation cessation, offering advantages over traditional fluorescent materials.
• Their ultra-long decay times effectively eliminate autofluorescence interference in biological applications.
• PLNPs have garnered significant attention in biomedicine due to their unique optical properties and potential for advanced diagnostics and therapeutics.

Purpose of the Study:

• To review recent advancements in the synthesis and preparation of persistent luminescence nanoparticles (PLNPs).
• To summarize the diverse applications of PLNPs in biosensing, bioimaging, and cancer therapy.
• To highlight the potential of PLNPs as a novel class of functional materials for biomedical applications.

Main Methods:

• Literature review of recent scientific publications on PLNPs.
• Analysis of studies focusing on PLNP preparation techniques.
• Compilation and categorization of PLNP applications in biosensing, bioimaging, and cancer therapy.

Main Results:

• PLNPs can be synthesized with tunable optical properties for specific biomedical tasks.
• The long-lasting luminescence of PLNPs enables sensitive bioimaging and bio-tracing with reduced background noise.
• PLNPs demonstrate efficacy in guiding cancer therapy with high signal-to-noise ratios and superior sensitivity.

Conclusions:

• Persistent luminescence nanoparticles represent a rapidly developing field with significant promise for biomedical applications.
• PLNPs offer unique advantages, including reduced autofluorescence and long emission times, for enhanced bioimaging, biosensing, and targeted cancer therapy.
• Continued research into PLNP preparation and application will likely lead to further breakthroughs in clinical diagnostics and treatment.