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Anaerobic Membrane Bioreactor for Continuous Lactic Acid Fermentation.

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Membrane bioreactor systems improve anaerobic lactic acid fermentation by removing the product, overcoming inhibition and boosting productivity. Controlling crossflow velocity via biomass concentration stabilized continuous fermentation performance.

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Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Industrial Microbiology

Background:

  • Anaerobic lactic acid fermentation is crucial for producing lactic acid.
  • High product concentrations inhibit glucose bioconversion, limiting fermentation productivity.
  • Membrane bioreactors offer a solution by enabling simultaneous product removal.

Purpose of the Study:

  • To enhance anaerobic lactic acid fermentation using a membrane bioreactor system.
  • To investigate methods for stabilizing membrane bioreactor performance during continuous fermentation.
  • To optimize process parameters for increased lactic acid productivity.

Main Methods:

  • Utilized ceramic membrane filtration for simultaneous lactic acid removal.
  • Controlled crossflow velocity by dynamically adjusting biomass concentration.
  • Employed real-time optical sensing for biomass monitoring.
  • Conducted continuous fermentation experiments.

Main Results:

  • Achieved stable lactic acid productivity of approximately 8 g·L-1·h-1.
  • Maintained lactic acid concentration around 40 g·L-1 at a dilution rate of 0.2 h-1.
  • Observed no residual sugar at a feed concentration of 50 g·L-1 under steady-state conditions.
  • Demonstrated that crossflow velocity is a key factor for stable flux, more so than transmembrane pressure.

Conclusions:

  • Membrane bioreactor systems effectively reduce product inhibition in anaerobic lactic acid fermentation.
  • Real-time monitoring and control of biomass concentration can stabilize membrane bioreactor performance.
  • The developed system enables high and stable lactic acid productivity in continuous fermentation.