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Related Concept Videos

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Related Experiment Video

Updated: Mar 3, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.

A Shusterman1, M Munz2,3, G Richter2

  • 11 Department of Prosthodontics, Hadassah Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel.

Journal of Dental Research
|May 4, 2017
PubMed
Summary
This summary is machine-generated.

This study identified novel genetic risk variants for periodontitis by combining mouse genetic data with human genome-wide association studies. The findings highlight specific genes associated with aggressive periodontitis, paving the way for better understanding of disease susceptibility.

Keywords:
GWASQTL mappingalveolar bone lossassociationgeneticmice model

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Area of Science:

  • Genetics
  • Oral Biology
  • Inflammatory Diseases

Background:

  • Periodontitis is a common inflammatory disease with high heritability, but previous genome-wide association studies (GWAS) have been limited by sample size and trait heterogeneity.
  • Identifying genetic susceptibility factors for periodontitis is crucial for understanding disease mechanisms and developing targeted interventions.

Purpose of the Study:

  • To discover novel genetic loci associated with periodontitis by integrating quantitative trait loci (QTL) mapping in mice with human GWAS data.
  • To identify specific genes and variants conferring risk for aggressive periodontitis (AgP) and chronic periodontitis (CP).

Main Methods:

  • Combined RNA-sequencing of gingival tissues with QTL analysis in a mouse model of oral pathogen infection.
  • Interrogated human orthologous chromosomal regions using GWAS data from German AgP and European American CP cohorts.
  • Validated associated variants in independent CP cohorts.

Main Results:

  • Four genes within mapped QTLs exhibited differential expression in the mouse model.
  • Two significant haplotype blocks associated with AgP were identified: one near UGT2A1 and another near PF4/PPBP/CXCL5.
  • The association near PF4/PPBP/CXCL5 (rs1595009) was successfully validated in two independent chronic periodontitis cohorts.

Conclusions:

  • The study successfully identified genetic risk variants for periodontitis by combining mouse genetic data with human association studies.
  • The findings demonstrate the utility of integrating multi-omics and cross-species data for discovering disease-associated loci.
  • Specific genetic variants near UGT2A1 and PF4/PPBP/CXCL5 are associated with periodontitis risk.