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Information Phage Therapy Research Should Report.

Stephen T Abedon1

  • 1Department of Microbiology, The Ohio State University, Mansfield, OH 44906, USA. abedon.1@osu.edu.

Pharmaceuticals (Basel, Switzerland)
|May 5, 2017
PubMed
Summary
This summary is machine-generated.

This study provides guidelines for reporting phage therapy and phage-mediated biocontrol experiments. Improved reporting enhances research reproducibility and clinical translation for these antibacterial virus applications.

Keywords:
bacteriophage therapybiocontrolbiological controlpeer reviewphage therapypharmacologypreclinical developmentpublicationregulation

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Area of Science:

  • Microbiology
  • Virology
  • Biotechnology

Background:

  • Bacteriophages (phages) are viruses that infect bacteria and have been used as antibacterial agents for nearly a century.
  • Phage therapy and phage-mediated biocontrol are established practices, but clinical translation requires high standards in preclinical research reporting.
  • Current regulations emphasize preclinical data, necessitating optimized reporting for effective clinical utility.

Purpose of the Study:

  • To provide recommendations for reporting preclinical and clinical phage therapy experiments.
  • To improve the quality and consistency of published phage therapy research.
  • To facilitate the translation of phage therapy findings from preclinical studies to clinical applications.

Main Methods:

  • The study proposes a list of essential information and data for phage therapy publications.
  • It offers best practice tips for authors, reviewers, and guideline formulators.
  • The recommendations aim to enhance the clarity and reproducibility of phage therapy research.

Main Results:

  • Optimized reporting standards are crucial for advancing phage therapy research.
  • Clearer reporting aids in repeating and extending research findings.
  • Improved reporting facilitates the transition from preclinical to clinical development.

Conclusions:

  • Adhering to standardized reporting practices will elevate the quality of phage therapy research.
  • Enhanced reporting ensures greater potential for clinical utility and broader application of phage-mediated biocontrol.
  • This work aims to improve the overall impact and reliability of phage therapy studies.