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Updated: Mar 3, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Prostate-derived Ets factor, an oncogenic driver in breast cancer
Ashwani K Sood1, Joseph Geradts2, Jessica Young3
11 Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Prostate-derived Ets factor (PDEF) is overexpressed in breast cancer, driving tumor growth. High PDEF levels correlate with poor survival, suggesting it as a therapeutic target and prognostic biomarker.
Area of Science:
- Molecular biology
- Oncology
- Genetics
Background:
- Prostate-derived Ets factor (PDEF) is an Ets family transcription factor.
- PDEF exhibits restricted normal tissue expression and a unique DNA-binding motif.
- Aberrant PDEF expression is observed in various cancers.
Purpose of the Study:
- To review PDEF expression characteristics and its role in breast cancer.
- To consolidate evidence on PDEF's oncogenic function in breast tumors.
- To discuss PDEF as a potential therapeutic target and prognostic biomarker.
Main Methods:
- Literature review of studies on PDEF expression and function in breast cancer.
- Analysis of PDEF expression patterns in normal and cancerous breast tissues.
- Correlation analysis of PDEF expression with clinical outcomes, including patient survival.
Main Results:
- PDEF is overexpressed in the majority of breast tumors.
- PDEF functions as an oncogenic transcription factor in breast cancer.
- Elevated PDEF expression in estrogen receptor-positive breast tumors correlates with poorer overall survival.
Conclusions:
- PDEF is an oncogenic driver in breast cancer.
- PDEF serves as a biomarker for poor prognosis in breast cancer patients.
- PDEF-targeted therapeutics may offer a strategy for breast cancer prevention and treatment due to its limited normal tissue expression.
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