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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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MANAGEMENT OF ENDOCRINE DISEASE: Present and future perspectives for medical therapy of nonfunctioning pituitary

Yona Greenman1

  • 1Institute of Endocrinology, Metabolism and Hypertension, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

European Journal of Endocrinology
|May 5, 2017
PubMed

Insights

For nonfunctioning pituitary adenomas (NFPA) after surgery, treatment options like watchful waiting, radiation, or medication lack comparative studies. This review explores off-label medication use for NFPA management.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Clinically nonfunctioning pituitary adenomas (NFPA) present treatment challenges post-surgery.
  • Evidence comparing watchful waiting, irradiation, and medical therapy for NFPA is limited.
  • No specific medical therapies are currently FDA-approved for NFPA treatment.

Purpose of the Study:

  • To review current data on medications approved for secreting pituitary adenomas, used off-label for NFPA.
  • To discuss treatment optimization strategies for NFPA.
  • To explore potential future therapeutic approaches for NFPA.

Main Methods:

  • Literature review of studies on pituitary adenoma treatments.
  • Analysis of off-label medication use in NFPA management.
  • Synthesis of data on approved drugs for secreting adenomas applied to NFPA.

Main Results:

  • Accumulating data suggests potential off-label efficacy of certain medications in NFPA.
  • Current treatment strategies for post-surgical NFPA lack robust comparative evidence.
  • Further research is needed to establish approved medical therapies for NFPA.

Conclusions:

  • Off-label use of medications approved for secreting pituitary adenomas warrants further investigation for NFPA.
  • Optimizing NFPA management requires exploring novel therapeutic avenues.
  • Future research should focus on comparative studies and developing approved NFPA treatments.

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