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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Does oxidative stress shorten telomeres?

Jelle J Boonekamp1, Christina Bauch2, Ellis Mulder2

  • 1Groningen Institute for Evolutionary Life Sciences, University of Groningen, PO Box 11103, 9700 CC Groningen, The Netherlands jjboonekamp@gmail.com.

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|May 5, 2017
PubMed
Summary
This summary is machine-generated.

Oxidative stress did not correlate with telomere shortening in young jackdaws. Cell proliferation dynamics, not oxidative stress, may drive telomere attrition in growing animals.

Keywords:
developmentmolecular ecologynestlingssomatic damagetelomere attrition

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Area of Science:

  • * Comparative physiology
  • * Molecular biology
  • * Avian ecology

Background:

  • * Oxidative stress is known to shorten telomeres in cell cultures.
  • * Its role in telomere attrition in vivo at physiological levels remains unclear.
  • * Nestling jackdaws exhibit rapid telomere attrition during early development.

Purpose of the Study:

  • * To investigate the relationship between oxidative stress markers and telomere attrition in nestling jackdaws.
  • * To determine if oxidative stress explains individual variation in telomere shortening in vivo.

Main Methods:

  • * Measured telomere attrition in jackdaws between 5 and 30 days old.
  • * Assessed six oxidative stress markers (damage and antioxidant) in blood at 20 days.
  • * Correlated oxidative stress markers with the rate of telomere attrition.

Main Results:

  • * Telomere attrition was highly variable among nestling jackdaws.
  • * No significant correlations were found between oxidative stress markers and telomere attrition (|r| ≤ 0.08).

Conclusions:

  • * Oxidative stress does not appear to significantly accelerate telomere attrition in vivo in this species.
  • * Cell proliferation dynamics may be a more critical factor in explaining telomere attrition variation in growing animals.