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Updated: Mar 3, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
The link between autophagy and secretion: a story of multitasking proteins
Hesso Farhan1, Mondira Kundu2, Susan Ferro-Novick3
1Institute of Basic Medical Sciences, University of Oslo, 3072 Oslo, Norway.
Abstract:
The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, there is mounting evidence that the secretory and autophagy pathways are intimately linked and that certain regulatory elements are shared between them. Here we highlight the parallels and points of intersection between these two evolutionarily highly conserved and fundamental endomembrane systems. The intersection of these pathways may play an important role in remodeling membranes during cellular stress.
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