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Hypercellular round cell liposarcoma: A comprehensive cytomorphologic study and review of 8 cases
Sanjay S Chufal1, Kundan S Chufal2, Prabhat Pant1
1Department of Pathology, Government Medical College, Haldwani, Uttarakhand, India.
Journal of Cytology
|May 5, 2017
Summary
Hypercellular round cell liposarcoma (RCL) diagnosis is aided by identifying neoplastic round cells adhering to capillaries (ANAC). This feature is crucial for distinguishing RCL from other round cell sarcomas when lipoblasts are absent.
Area of Science:
- Surgical pathology
- Cytopathology
- Oncology
Background:
- Myxoid and round cell liposarcomas (RCL) represent a histologic continuum of liposarcoma (LPS) subtypes.
- RCL can present as low or high-grade tumors.
Purpose of the Study:
- To investigate the cytomorphology of hypercellular RCL.
- To identify features differentiating hypercellular RCL from other round cell sarcomas with myxoid change.
Main Methods:
- Retrospective analysis of eight hypercellular RCL cases (round cell component >75%).
- Detailed study of cytomorphological features.
Main Results:
- Four cases were predominantly round cell; two were entirely round cell.
- Myxoid stroma was absent in two cases.
- Adherence of neoplastic round cells around thin capillaries (ANAC) was observed in seven cases; plexiform capillaries in four.
Conclusions:
- ANAC is a consistent and important diagnostic clue for hypercellular RCL, especially when lipoblasts are not apparent.
- Plexiform capillary plexus and ANAC should be evaluated separately.
- Confident diagnosis of hypercellular RCL can be made based on ANAC.
