Exocytosis, Endocytosis, and Their Coupling in Excitable Cells

Evoked exocytosis in excitable cells is fast and spatially confined and must be followed by coupled endocytosis to enable sustained exocytosis while maintaining the balance of the vesicle pool and the plasma membrane. Various types of exocytosis and endocytosis exist in these excitable cells, as those has been found from different types of experiments conducted in different cell types. Correlating these diversified types of exocytosis and endocytosis is problematic. By providing an outline of different exocytosis and endocytosis processes and possible coupling mechanisms here, we emphasize that the endocytic pathway may be pre-determined at the time the vesicle chooses to fuse with the plasma membrane in one specific mode. Therefore, understanding the early intermediate stages of vesicle exocytosis may be instrumental in exploring the mechanism of tailing endocytosis.