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Updated: Jul 25, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
Published on: January 23, 2018
Zoledronic acid for neonatal subcutaneous fat necrosis
Jeremy A Di Bari1, Jennifer A Nead2, Scott J Schurman3
1Resident, Family MedicineSt. Joseph's Hospital Health Center 301 Prospect Ave Syracuse New York 13203 USA.
Abstract:
Subcutaneous fat necrosis (SFN) in infants producing severe hypercalcemia is a life-threatening emergency. Pathophysiology may include enhanced gastrointestinal calcium absorption and bone resorption. We treated an infant with SFN and serum calcium of 15 mg/dL with prednisolone and low-dose zoledronic acid. Serum calcium promptly normalized without rebound hypocalcemia, and redosing of zoledronic acid was not necessary.
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