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Implementing a multi-faceted strategy significantly improved timely antibiotic administration for neutropenic sepsis patients. This approach ensures rapid recognition and treatment, reducing critical care delays and improving patient outcomes in cancer therapy.

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Healthcare Management

Background:

  • Neutropenic sepsis is a life-threatening complication of cancer treatment.
  • A national target exists for administering antibiotics within one hour of presentation.
  • Initial audits revealed significant delays in antibiotic delivery within the Belfast Trust.

Purpose of the Study:

  • To improve the timely recognition and management of neutropenic sepsis.
  • To increase the percentage of patients receiving first-dose antibiotics within the target one-hour timeframe.

Main Methods:

  • Introduction of an integrated care pathway for suspected neutropenic sepsis.
  • Implementation of a user-friendly care pathway following initial disappointing results.
  • Utilizing ward-based documentation for continuous monitoring.
  • Facilitating nurse-led prescribing and antibiotic administration via patient group directions.
  • Conducting regular multidisciplinary education and improving access to guidelines.

Main Results:

  • Baseline audit showed only 15% of patients met the one-hour target.
  • Re-audits showed initial improvement to 62%, followed by a decline to 50%.
  • Post-November 2013, consistently over 80% of patients met the target.
  • Recent data (July 2016) shows 100% adherence, with 95% in October.

Conclusions:

  • A combination of interventions led to significant and sustained improvements in meeting the one-hour antibiotic administration target.
  • The standardized, coordinated approach ensures prompt and safe clinical care for neutropenic sepsis.
  • These improvements aim to prevent complications associated with delayed treatment.