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Updated: Mar 3, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Esophageal squamous papilloma lacks clear clinicopathological associations
Bilel Jideh1, Martin Weltman1, Yang Wu1
1Bilel Jideh, Martin Weltman, Yang Wu, Calvin H Y Chan, Department of Gastroenterology and Hepatology, Nepean Hospital, Sydney, NSW 2747, Australia.
Aim:
To determine the prevalence of esophageal squamous papillomas (ESPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas (SCCs).
Methods:
Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed.
Results:
ESP was found in sixteen patients (0.23%). Eight (50%) patients had a high body mass index, seven (44%) had history of cigarette smoking. Reflux esophagitis was found in four (25%) patients. All ESPs were solitary with a mean endoscopic size of 3.8 mm and located in the mid to lower esophagus. Human papilloma virus (HPV) was tested in three (19%) patients and was negative. Esophageal SCC was found in seven patients (0.10%) during the same period. None of the specimens were tested for HPV, and none had associated papillomatous changes.
Conclusion:
ESP is an uncommon tumour with unclear clinical associations and malignant potential.
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