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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus
Chang-Ling Hu1, Juan Xiong1, Chen-Xi Xiao2
1a Department of Natural Products Chemistry , School of Pharmacy, Fudan University , Shanghai 201203 , China.
Abstract:
Ten diterpenoids including three new abietanes (1-3) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3β-hydroxy-abieta-8,11,13-trien-7-one (5), decandrin G (6), and 7,15-pimaradien-18-oic acid (8) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC50 values of 3.7, 11.1, and 4.5 μM, respectively.
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