Related Experiment Video
Updated: Mar 3, 2026
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks
Nicola J Armstrong1,2, Karen A Mather1, Anbupalam Thalamuthu1
1Centre for Healthy Brain Aging, School of Psychiatry, UNSW Australia, Sydney, Australia.
Aim:
To examine the relationships between two epigenetic clocks, aging and exceptional longevity.
Materials & Methods:
Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks.
Results:
Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model.
Conclusion:
Long-lived individuals have a young epigenetic age compared with their chronological age.
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