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Updated: Sep 21, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems
Diana Gimenez1, Caitlin A Mooney, Anica Dose
1Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK. c.r.coxon@ljmu.ac.uk s.l.cobb@durham.ac.uk.
Abstract:
The perfluoroheteroaromatic reagent pentafluoropyridine has proved to be a highly reactive electrophile, undergoing SNAr arylation reactions in the presence of a range of nucleophilic peptide side chains (i.e. cysteine, tyrosine, serine and lysine) under mild conditions. Moreover, we have shown how one-step peptide-modification using perfluoroheteroaromatics can deliver enhanced proteolytic stability in pharmaceutically-relevant peptides such as oxytocin.
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