Related Experiment Video
Updated: Mar 3, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Tumor treating fields in pediatric high-grade glioma
Adam L Green1,2, Jean M Mulcahy Levy3,4, Rajeev Vibhakar3,4
1Program in Neuro-Oncology, Center for Cancer and Blood Disorders, Children's Hospital Colorado, 12800 E. 19th Ave. RC1-N, Mail Stop 8302, Aurora, CO, 80045, USA. adam.green@ucdenver.edu.
Purpose:
Tumor treating fields (TTF) are alternating electric fields applied continuously to the scalp. The treatment is approved for both primary and recurrent supratentorial adult glioblastoma but unstudied in children.
Methods:
We report a feasibility case series of five pediatric high-grade glioma patients (ages 10-20 years) treated at our institution with TTF along with chemotherapy and/or radiation.
Results:
Two patients began therapy at second recurrence and showed progressive disease. Two others were treated upfront after radiation therapy, and both showed partial responses. A fifth patient was treated at first recurrence and also showed a partial response. All five tolerated TTF well without treatment-limiting toxicities.
Conclusions:
The tolerability of TTF, combined with the adult data, justify a pediatric clinical trial.
