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Continuously Grooved Stent Struts for Enhanced Endothelial Cell Seeding.

Marja Ter Meer1, Willeke F Daamen2, Yvonne L Hoogeveen3

  • 1Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. marja.termeer@radboudumc.nl.

Cardiovascular and Interventional Radiology
|May 5, 2017
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Summary

Grooved stents effectively carry endothelial cells (ECs), enhancing vessel repair. These stents offer superior EC attachment and protection during deployment, improving outcomes in vascular interventions.

Keywords:
316L stainless steelCell adhesionEndothelializationEndovascular stentIn vitroNitinol

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Area of Science:

  • Biomaterials Engineering
  • Vascular Biology
  • Regenerative Medicine

Background:

  • Pre-endothelialized stents aim to improve vessel healing after implantation.
  • Cell viability, function, and number are critical for successful stent-based cell delivery.
  • Evaluating novel stent designs for enhanced endothelial cell (EC) attachment and protection is crucial.

Purpose of the Study:

  • To assess the feasibility of grooved stainless steel (SS) stents as endothelial cell (EC) carriers.
  • To evaluate the protective effect of grooved SS stents on ECs during deployment.
  • To compare the performance of grooved SS stents with smooth SS and nitinol stents.

Main Methods:

  • Human adult venous endothelial cells (ECs) were seeded onto gelatin-coated vascular stents in vitro.
  • Attachment and behavior of ECs on smooth and grooved SS stents, and smooth nitinol stents were analyzed.
  • Rotational seeding was employed for 16-24 hours, followed by simulated deployment and pulsatile flow testing.

Main Results:

  • ECs firmly attached to stents, forming confluent monolayers expressing vWF and CD31.
  • Grooved SS stents accommodated three times more ECs than smooth wires.
  • Grooved stents retained more ECs after deployment and pulsatile flow (180 ml/min for 24h) without significant detachment.

Conclusions:

  • Grooved stents serve as effective carriers for delivering sufficient viable and functional endothelial cells (ECs) during vascular interventions.
  • The grooved design provides a favorable surface for EC attachment and enhances EC protection during stent deployment.
  • This approach offers a potential percutaneous method for cell-based vascular repair.