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Interfacing Biocompatible Reactions with Engineered Escherichia coli.

Stephen Wallace1,2, Emily P Balskus3

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA.

Methods in Molecular Biology (Clifton, N.J.)
|May 5, 2017
PubMed
Summary

Biocompatible chemistry merges chemical and biological synthesis for producing novel molecules via microbial fermentation. Key criteria include aqueous functionality, non-toxicity to microbes, and minimal metabolic pathway interference.

Keywords:
Biocompatible chemistryCyclopropanationHydrogenationMetabolic engineeringSynthetic biology

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Area of Science:

  • Biotechnology
  • Synthetic Biology
  • Chemical Biology

Background:

  • Biocompatible chemistry integrates nonenzymatic reactions with metabolic pathways.
  • This enables microbial fermentation for producing nonnatural molecules from renewable resources.

Purpose of the Study:

  • To outline procedures for developing new biocompatible reactions.
  • To detail chemical and microbiological considerations for biocompatible reaction development.

Main Methods:

  • Detailed outline of two biocompatible reaction procedures: hydrogenation and cyclopropanation.
  • Description of chemical and microbiological experiments and considerations.

Main Results:

  • Established criteria for functional biocompatible reactions: aqueous media compatibility, microbial non-toxicity, and metabolic pathway neutrality.
  • Demonstrated applicability of hydrogenation and cyclopropanation as biocompatible reactions.

Conclusions:

  • Biocompatible chemistry offers a novel platform for sustainable synthesis of complex molecules.
  • Successful development requires careful consideration of reaction conditions and microbial impact.