Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Rare vascular variant: supratemporal retinal artery with ciliary perfusion].

Die Ophthalmologie·2026
Same author

SD-OCT-histopathologic correlation in Schnabel's cavernous optic nerve atrophy.

Eye (London, England)·2025
Same author

Prosthetic Visual Acuity with the PRIMA System in Patients with Atrophic Age-related Macular Degeneration at 4 years follow-up.

medRxiv : the preprint server for health sciences·2023
Same author

[Differential diagnosis of eyelid tumors in children: subepidermal calcified nodule].

Die Ophthalmologie·2023
Same author

[Retinal optical coherence tomography biomarkers in dementia].

Die Ophthalmologie·2023
Same author

[Bottlenecks in the availability of ophthalmological medications : Initiative of the Working Group on Ethics in Ophthalmology of the DOG and the University Eye Clinic Bonn].

Die Ophthalmologie·2022
Same journal

Corneal Neurotisation in Neurotrophic Keratopathy: A Retrospective Analysis of Functional Outcomes and Clinical Courses.

Klinische Monatsblatter fur Augenheilkunde·2026
Same journal

Evaluating the Long-term Success and Safety of Canaloplasty in Glaucoma Patients.

Klinische Monatsblatter fur Augenheilkunde·2026
Same journal

Imbalanced Trace Elements as Risk Factors in the Pathogenesis of Glaucoma.

Klinische Monatsblatter fur Augenheilkunde·2026
Same journal

Malnutrition as a Risk Factor for Cerebral and Glaucomatous Neurodegeneration - Mechanisms and Therapeutic Strategies.

Klinische Monatsblatter fur Augenheilkunde·2026
Same journal

Impact of Wearing a Face Mask on the Reliability of Standard Automated Perimetry in Glaucoma Patients and Suspects: a Retrospective Longitudinal Study.

Klinische Monatsblatter fur Augenheilkunde·2026
Same journal

[Siderotic Cataract Eight Months After Intralenticular Metallic Foreign Body: A Case Report and Surgical Management].

Klinische Monatsblatter fur Augenheilkunde·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.5K

[Morphologic Corneal Changes after Crosslinking for Keratoconus].

P L Müller1,2, K U Löffler1,2, M Kohlhaas3

  • 1Universitäts-Augenklinik Bonn, Bonn, Deutschland.

Klinische Monatsblatter Fur Augenheilkunde
|May 5, 2017
PubMed
Summary
This summary is machine-generated.

Corneal crosslinking is an effective, low-risk treatment for progressive keratoconus (an eye disease). This review examines how crosslinking changes corneal structure and biomechanics.

More Related Videos

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.1K
Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
06:46

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

12.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.5K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.1K
Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
06:46

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

12.6K

Area of Science:

  • Ophthalmology
  • Corneal Science
  • Biomaterials

Background:

  • Keratoconus is a common bilateral corneal disease characterized by thinning and ectasia.
  • It involves significant biochemical and biomechanical structural changes.
  • Corneal crosslinking (CXL) has been a therapeutic option for over a decade.

Purpose of the Study:

  • To review the physiologic and pathologic changes in keratoconic corneas before and after crosslinking.
  • To consolidate current knowledge on CXL effectiveness and safety.
  • To present original histopathologic findings.

Main Methods:

  • Review of published literature on keratoconus and crosslinking.
  • Histopathologic examination of corneal tissues.
  • Analysis of riboflavin and UVA-radiation effects on corneal stroma.

Main Results:

  • Crosslinking stiffens the anterior corneal stroma (300 µm) by crosslinking collagen fibers.
  • The procedure is effective and low-risk when protocols are followed.
  • Detailed understanding of pre- and post-crosslinking corneal changes.

Conclusions:

  • Corneal crosslinking is a well-established treatment for progressive keratoconus.
  • Adherence to protocols ensures efficacy and safety.
  • Further histopathologic insights complement existing knowledge on CXL outcomes.