Related Experiment Video For Cervical intraepithelial lesions
Updated: Mar 3, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions?
Emre Özgü1, Nafiye Yılmaz2, Eralp Başer1
1Department of Gynecologic Oncology, Zekai Tahir Burak Women Health Education and Research Hospital, Ankara, Turkey.
Abstract:
Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti- proliferative, pro- apoptotic, anti- angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency. As a result of the study the difference of 25-OH Vitamin D3 levels between HPVDNA positive group and the control group were statistically significant (p=0,009). According to results of our study, with the proven anti-inflammatory functions of Vitamin D, the deficiency of these molecule and its metabolites can be a possible reason for HPVDNA persistence and related cervical intraepithelial neoplasia.
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