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Updated: Mar 3, 2026

Detection of Viral RNA by Fluorescence in situ Hybridization FISH
Published on: May 5, 2012
Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids
Caroline Ross1, Caroline Knox1, Özlem Tastan Bishop1
1Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Abstract:
Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.
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