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Hemophagocytic lymphohistiocytosis in patients with metastatic malignant melanoma
Sarah Stabler1, Coralie Becquart, Florent Dumezy
1Departments of aDermatology bInternal Medicine, Hôpital Huriez cDepartment of Biological Hematology, Biology and Pathology Center, University of Lille Medical School, Lille, France.
Abstract:
Hemophagocytic lymphohistiocytosis (HLH) is an autoinflammatory disease that classically occurs because of infections, autoinflammatory, or autoimmune diseases, hematologic cancers, and rarely because of solid tumor. We report a rare case of HLH attributed to metastatic malignant melanoma treated without corticosteroid and with a nonfatal outcome thanks to specific therapies: etoposide for HLH and a selective inhibitor of mutated forms of BRAF kinase associated with a MEK inhibitor for melanoma.
