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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Geriatric syndromes: new frontiers in HIV and sarcopenia

Kellie L Hawkins1, Todd T Brown, Joseph B Margolick

  • 1aUniversity of Colorado, Aurora, Colorado bJohns Hopkins School of Medicine cJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

AIDS (London, England)
|May 5, 2017
PubMed

Insights

Older adults with HIV experience accelerated aging and geriatric syndromes like sarcopenia. Early recognition and prevention are crucial for managing these age-related conditions in HIV patients.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Public Health

Background:

  • Combination antiretroviral therapy (ART) has transformed HIV infection into a manageable chronic condition, increasing life expectancy for patients.
  • As HIV-positive individuals age, the long-term effects of chronic infection and its management on health are becoming a significant research area.
  • People living with HIV often experience earlier onset of aging-related conditions compared to HIV-negative individuals due to comorbidities, lifestyle factors, chronic inflammation, and ART.

Purpose of the Study:

  • This review focuses on sarcopenia, a key geriatric syndrome, in aging populations with HIV.
  • It examines the relationship between sarcopenia, frailty, and falls in this demographic.
  • The review highlights the roles of HIV, ART, and comorbidities in these aging syndromes and emphasizes early detection and prevention strategies.

Main Methods:

  • This is a review article, synthesizing existing research on aging syndromes in HIV-infected populations.
  • It analyzes the contribution of HIV infection, antiretroviral therapy (ART), and comorbidities to the development of geriatric syndromes.
  • The focus is on sarcopenia, frailty, and falls in older adults living with HIV.

Main Results:

  • People living with HIV show an earlier onset of aging-related conditions and geriatric syndromes.
  • Sarcopenia, frailty, and falls are significant concerns in older HIV-infected individuals.
  • Chronic inflammation, comorbidities, and ART-related factors contribute to accelerated aging in this population.

Conclusions:

  • HIV-infected individuals are at higher risk for premature aging and associated geriatric syndromes like sarcopenia.
  • Understanding the interplay of HIV, ART, and comorbidities is essential for addressing these age-related issues.
  • Early identification and proactive management of sarcopenia and related syndromes are critical for improving health outcomes in aging HIV populations.

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