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Updated: Mar 3, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates
Allyson J Boyington1, Martin-Louis Y Riu1, Nathan T Jui1
1Department of Chemistry, Winship Cancer Institute, Emory University , Atlanta, Georgia 30322, United States.
Abstract:
The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.
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