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Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and

Mary Gemmel1, Eszter Bögi2, Christina Ragan3

  • 1Department of Biological Sciences, Ohio University, Athens, OH, USA.

Neuroscience and Biobehavioral Reviews
|May 5, 2017
PubMed

Insights

Perinatal exposure to selective serotonin reuptake inhibitors (SSRIs) may alter offspring social behaviors and neurodevelopment. This review examines SSRI impacts on maternal care, social behaviors, neurobiology, and the epigenome in developing children.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are increasingly used during pregnancy.
  • Serotonin plays a crucial role in neurodevelopment and social behavior.
  • Maternal SSRI use raises questions about potential effects on the developing child.

Purpose of the Study:

  • To review the impact of perinatal SSRI exposure on maternal care and neurodevelopmental outcomes.
  • To examine alterations in social behaviors, including play, social interactions, and reproduction.
  • To discuss the effects on neurobiology and the epigenome.

Main Methods:

  • Review of clinical research findings.
  • Analysis of data from animal models.
  • Synthesis of existing literature on SSRI effects.

Main Results:

  • Perinatal SSRI exposure can modify maternal care and offspring social behaviors.
  • Neurobiological and epigenetic changes are associated with early life SSRI exposure.
  • Effects on social affiliative behaviors and reproductive outcomes are observed.

Conclusions:

  • Understanding SSRI impacts is vital for child neurodevelopment and well-being.
  • Further research is needed to fully elucidate the long-term consequences.
  • This knowledge can inform clinical practice and improve intergenerational health outcomes.

Keywords:
AntidepressantDevelopmentMaternal anxietyMaternal careMaternal stressOffspringPerinatal depressionPlay behaviorPregnancyReproductive behaviorSSRISerotoninSex differencesSocial interactionStress

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