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Molecular Imaging of PARP
Brandon Carney1,2, Susanne Kossatz1, Thomas Reiner3,4
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.
Insights
Poly(adenosine diphosphate-ribose)polymerase (PARP) imaging utilizes fluorescent or radiolabeled tags to visualize cellular DNA damage response. This review details PARP imaging agents and their clinical applications in disease, especially cancer.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Poly(adenosine diphosphate-ribose)polymerase (PARP) enzymes are crucial for DNA damage repair.
- PARP's role in cancer pathogenesis has led to therapeutic strategies.
- Molecular imaging of PARP is emerging due to successful therapeutic inhibitors.
Purpose of the Study:
- To review the evolution of PARP imaging agents.
- To discuss the current technological advancements in PARP imaging.
- To highlight the clinical applications of PARP imaging in disease management.
Main Methods:
- Literature review of PARP imaging agents.
- Analysis of historical and current imaging technologies.
- Focus on clinical translation and applications.
Main Results:
- Overview of early PARP imaging agents.
- Discussion of modern fluorescent and radiolabeled PARP probes.
- Examples of clinical utility in various diseases, particularly cancer.
Conclusions:
- PARP imaging has advanced significantly, mirroring therapeutic progress.
- Current imaging agents show promise for clinical diagnostics and treatment monitoring.
- Further development is expected to enhance clinical applications of PARP imaging.
