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Related Experiment Video

Updated: Mar 3, 2026

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
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Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing.

Lok-Kin Yeung1, Rosanna K Olsen2, Hannah E P Bild-Enkin3

  • 1Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada, ly2143@cumc.columbia.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 6, 2017
PubMed
Summary

The anterolateral entorhinal cortex (alERC) volume predicts configural processing in older adults. This finding offers insights into early Alzheimer's disease pathology and potential detection methods.

Keywords:
MRI volumetryanterolateral entorhinal cortexconfigural processingeye trackingmedial temporal lobemild cognitive impairment

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • The human entorhinal cortex (ERC) is functionally divided into anterolateral (alERC) and posteromedial (pmERC) subregions.
  • The alERC is affected early in Alzheimer's disease, but its cognitive function is unclear.
  • Rodent studies suggest the lateral entorhinal cortex is involved in spatial object properties, contrasting with human fMRI studies focusing on object memory.

Purpose of the Study:

  • To investigate the cognitive effects of human alERC volume differences.
  • To evaluate intra-item configural processing using an eye-tracking task.
  • To delineate alERC/pmERC and other medial temporal lobe (MTL) subregions via manual segmentation.

Main Methods:

  • Developed an eye-tracking task to assess intra-item configural processing.
  • Utilized manual segmentation based on a new protocol to define MTL subregions.
  • Recruited older adults with varying stages of brain atrophy and cognitive decline.

Main Results:

  • alERC volume strongly predicted intra-item configural processing, irrespective of object novelty.
  • No other MTL subregion volume predicted configural processing.
  • This is the first study linking human alERC volume to a specific cognitive function.

Conclusions:

  • The human alERC supports a distinct aspect of object processing: attending to the arrangement of an object's features.
  • The findings provide crucial insights into the cognitive role of the alERC in aging and neurodegeneration.
  • The developed task shows potential for early detection of Alzheimer's disease pathology.