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Peripheral aromatization: studies on controlling factors.

C Longcope1

  • 1Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester 01605.

Steroids
|July 1, 1987
PubMed
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Peripheral aromatization of androgens varies across species and is influenced by hormonal factors. Postmenopausal women show increased aromatization, while thyroid hormone can enhance it in certain primates.

Area of Science:

  • Endocrinology
  • Biochemistry
  • Comparative Physiology

Background:

  • Peripheral aromatization, the conversion of androgens to estrogens, is a key endocrine process.
  • Understanding species-specific differences and regulatory factors is crucial for endocrine research.

Purpose of the Study:

  • To investigate the peripheral aromatization of androgens across various species.
  • To examine the effects of hormonal interventions (ACTH, glucocorticoids, l-thyroxine) on aromatization.
  • To identify potential inhibitors of peripheral aromatization.

Main Methods:

  • Constant infusions of radiolabeled androgens (3H) and estrogens (14C).
  • Measurement of radiolabeled estrogens in blood and urine.
  • Comparative studies in humans, nonhuman primates (cynomolgus monkeys, rhesus monkeys, baboons), sheep, and rabbits.

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Main Results:

  • Aromatization increases in postmenopausal women.
  • ACTH and glucocorticoids slightly decrease androstenedione aromatization in humans and cynomolgus monkeys.
  • L-thyroxine increases androstenedione aromatization in cynomolgus monkeys.
  • Peripheral aromatization is similar in humans and several primate species but lower in sheep and rabbits.
  • 10-(2-propynyl)-estr-4-ene-3,17-dione effectively inhibits aromatization.

Conclusions:

  • Peripheral androgen aromatization exhibits significant interspecies variation.
  • Hormonal factors, including thyroid hormone, can modulate aromatization rates.
  • A novel compound demonstrates potent inhibition of peripheral aromatization.